منابع مشابه
Contribution of Peroxynitrite, a Reactive Nitrogen Species, in the Pathogenesis of Autoimmunity
Peroxynitrite is a member of reactive nitrogen species that also includes nitric oxide (·NO) and nitrogen dioxide radical (NO2). Peroxynitrite is a reactive nitrogen species and an anion with the formula (ONOO−). It is an unstable ‘valence isomer’ of nitrate (NO3−), making it an oxidant and nitrating agent. Because of its oxidizing properties, peroxynitrite can damage a wide range of molecules ...
متن کاملThe reactive nitrogen species peroxynitrite is a potent inhibitor of renal Na-K-ATPase activity.
Peroxynitrite is a reactive nitrogen species produced when nitric oxide and superoxide react. In vivo studies suggest that reactive oxygen species and, perhaps, peroxynitrite can influence Na-K-ATPase function. However, the direct effects of peroxynitrite on Na-K-ATPase function remain unknown. We show that a single bolus addition of peroxynitrite inhibited purified renal Na-K-ATPase activity, ...
متن کاملpH-dependent changes of nitric oxide, peroxynitrite, and reactive oxygen species in hepatocellular damage.
Low arterial blood pH and sustained nitric oxide (NO) production are critical parameters in inflammatory events such as sepsis, and appropriate treatment is still under debate. Because the stability of nitrogen and oxygen intermediates is dependent on the surrounding pH, we investigated whether the relationship among NO, peroxynitrite (ONOO-), and reactive oxygen species production also depends...
متن کاملXanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite.
We hypothesized that in hyperhomocysteinemia (HHcy), flow-induced arteriolar constriction is due to an enhanced generation of reactive oxygen and/or nitrogen species, causing an impairment of nitric oxide (NO) and prostaglandin mediation of the response. Changes in diameter of isolated, pressurized (at 80 mm Hg) gracilis muscle arterioles (diameter approximately 170 microm) from control and met...
متن کاملOH-radical-type reactive oxygen species: a short review on the mechanisms of OH-radical- and peroxynitrite toxicity.
=> There is ROS-formation concerning signal transfer, regulation of intermediary metabolism as well as influence on induction and efficiency of immune answers. These processes are under metabolic control and deviations from steadystate equilibria are rare under physiological conditions. => There are ROS on the other side which escape metabolic control and concommitantly also in trinsic scaveng...
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ژورنال
عنوان ژورنال: Chemical Research in Toxicology
سال: 1998
ISSN: 0893-228X,1520-5010
DOI: 10.1021/tx980500u